Outcomes of interest were cognitive performance (MoCA scores) and physical frailty (CHS frailty score) over a follow-up period of 6 and 12 months. Measurementsīaseline IC was measured by 5 subdomains, including cognition (Montreal Cognitive Assessment, MoCA), sensory (visual and hearing impairment), vitality (handgrip strength or Mini-Nutritional Assessment-short form), psychological well-being (Geriatric Depression Scale-5), and locomotion (6m gait speed). InterventionĪ 12-month pragmatic multidomain intervention of exercise, cognitive training, nutritional counseling and chronic condition management. Setting and Participants: 1,054 community-dwelling older adults from 40 community-based clusters across Taiwan. DesignĪ cluster-randomized controlled trial. To examine roles of baseline IC and its subdomains on the efficacy of multidomain interventions in promoting healthy aging in older adults. Existing evidence suggests that multidomain interventions have the potential to enhance cognitive performance and yield positive effects on physical frailty. doi:10.1212/WNL.Impaired intrinsic capacity (IC), which affects approximately 90% of older adults, is associated with a significantly heightened risk of frailty and cognitive decline. Alzheimer disease in the United States (2010–2050) estimated using the 2010 census. Hebert LE, Weuve J, Scherr PA, & Evans DA (2013). Dementia and Geriatric Cognitive Disorders, 45(1–2), 49–55. Incremental Validity of Montreal Cognitive Assessment Index Scores in Mild Cognitive Impairment and Alzheimer Disease. Goldstein FC, Milloy A, & Loring DW (2018). Clinically concordant variations of Alzheimer pathology in aphasic versus amnestic dementia. Gefen T, Gasho K, Rademaker A, Lalehzari M, Weintraub S, Rogalski E, … Mesulam MM (2012).

Gauthier S, Reisberg B, Zaudig M, Petersen RC, Ritchie K, Broich K, … International Psychogeriatric Association Expert Conference on mild cognitive, i. Approach to atypical Alzheimer’s disease and case studies of the major subtypes. MoCA Index scores can help differentiate among distinct cognitive syndromes, suggesting it may be a useful brief screening tool to detect domain-specific cognitive impairment.Īlzheimer’s disease Assessment Cognition Dementias Neurodegeneration Primary progressive aphasia.ĭickerson BC, McGinnis SM, Xia C, Price BH, Atri A, Murray ME, … Wolk DA (2017). Multivariate logistic regression analysis showed that the individual effects of Memory (p =. 001), whereas Language and Attention Index scores were lowest in the PPA group (p <. However, in accordance with salient clinical features commonly observed in DAT versus PPA, Memory and Orientation Index scores were lowest in the DAT group (p <. 001) but did not differ between DAT and PPA groups. The mean MoCA total score was significantly higher in controls compared to both patient groups (p <. A logistic regression model was implemented to observe individual likelihood of group affiliation based on MoCA Index scores. A one-way analysis of covariance adjusted for age was used to compare MoCA scores among groups. This study compared MoCA Index scores between amnestic dementia of the Alzheimer's type (DAT) and primary progressive aphasia (PPA), a language-based dementia.īaseline MoCA data were analyzed from 33 DAT, 37 PPA, and 83 cognitively normal individuals enrolled in the Clinical Core of the Northwestern Alzheimer's Disease Center. It is unclear whether these MoCA scores can differentiate between distinct clinical dementia syndromes. The MoCA generates a total score and six domain-specific index scores: (1) Memory, (2) Executive Functioning, (3) Attention, (4) Language, (5) Visuospatial, and (6) Orientation. The Montreal Cognitive Assessment (MoCA) is a popular and simple-to-administer screening instrument to detect cognitive impairment.

Cognitive domains assessed by moca